Inferring meta-covariates in classification

This paper develops an alternative method for gene selection that combines model based clustering and binary classification. By averaging the covariates within the clusters obtained from model based clustering, we define “meta-covariates” and use them to build a probit regression model, thereby selecting clusters of similarly behaving genes, aiding interpretation. This simultaneous learning task is accomplished by an EM algorithm that optimises a single likelihood function which rewards good performance at both classification and clustering. We explore the performance of our methodology on a well known leukaemia dataset and use the Gene Ontology to interpret our results

Order Parameter Description of the Anderson-Mott Transition

An order parameter description of the Anderson-Mott transition (AMT) is given. We first derive an order parameter field theory for the AMT, and then present a mean-field solution. It is shown that the mean-field critical exponents are exact above the upper critical dimension. Renormalization group methods are then used to show that a random-field like term is generated under renormalization. This leads to similarities between the AMT and random-field magnets, and to an upper critical dimension $d_{c}^{+}=6$ for the AMT. For $d<6$, an $\epsilon = 6-d$ expansion is used to calculate the critical exponents. To first order in $\epsilon$ they are found to coincide with the exponents for the random-field Ising model. We then discuss a general scaling theory for the AMT. Some well established scaling relations, such as Wegner's scaling law, are found to be modified due to random-field effects. New experiments are proposed to test for random-field aspects of the AMT.Comment: 28pp., REVTeX, no figure

Theory of Disordered Itinerant Ferromagnets I: Metallic Phase

A comprehensive theory for electronic transport in itinerant ferromagnets is developed. We first show that the Q-field theory used previously to describe a disordered Fermi liquid also has a saddle-point solution that describes a ferromagnet in a disordered Stoner approximation. We calculate transport coefficients and thermodynamic susceptibilities by expanding about the saddle point to Gaussian order. At this level, the theory generalizes previous RPA-type theories by including quenched disorder. We then study soft-mode effects in the ferromagnetic state in a one-loop approximation. In three-dimensions, we find that the spin waves induce a square-root frequency dependence of the conductivity, but not of the density of states, that is qualitatively the same as the usual weak-localization effect induced by the diffusive soft modes. In contrast to the weak-localization anomaly, this effect persists also at nonzero temperatures. In two-dimensions, however, the spin waves do not lead to a logarithmic frequency dependence. This explains experimental observations in thin ferromagnetic films, and it provides a basis for the construction of a simple effective field theory for the transition from a ferromagnetic metal to a ferromagnetic insulator.Comment: 15pp., REVTeX, 2 eps figs, final version as publishe

Combination Rules, Charge Symmetry, and Hall Effect in Cuprates

The rule relating the observed Hall coefficient to the spin and charge responses of the uniform doped Mott insulator is derived. It is essential to include the contribution of holon and spinon three-current correlations to the effective action of the gauge field. In the vicinity of the Mott insulating point the Hall coefficient is holon dominated and weakly temperature dependent. In the vicinity of a point of charge conjugation symmetry the holon contribution to the observed Hall coefficient is small: the Hall coefficient follows the temperature dependence of the diamagnetic susceptibility with a sign determined by the Fermi surface shape. NOTE: document prepared using REVTEX. (3 Figs, not included, available on request from: [email protected])Comment: 8 page

Magpie: towards a semantic web browser

Web browsing involves two tasks: finding the right web page and then making sense of its content. So far, research has focused on supporting the task of finding web resources through ‘standard’ information retrieval mechanisms, or semantics-enhanced search. Much less attention has been paid to the second problem. In this paper we describe Magpie, a tool which supports the interpretation of web pages. Magpie offers complementary knowledge sources, which a reader can call upon to quickly gain access to any background knowledge relevant to a web resource. Magpie automatically associates an ontologybased semantic layer to web resources, allowing relevant services to be invoked within a standard web browser. Hence, Magpie may be seen as a step towards a semantic web browser. The functionality of Magpie is illustrated using examples of how it has been integrated with our lab’s web resources

A Co-axial Multi-tube Heat Exchanger Applicable for a Geothermal ORC Power Plant

AbstractThe study proposes a Co-axial multi-tube heat exchanger (CMTHE) applicable to geothermal heat extraction. The heat exchanger is integrated with a 50kW geothermal ORC power plant having a working fluid of R-245fa. Two field tests were performed to examine the system response of the ORC system subject to change of CMTHE. In case 1 where the flow rate in the shell-side of CMTHE is maintained, the pressure variation in the shell-side of CMTHE casts minor variations on heat extraction, ORC power generation, and ORC efficiency during the transient. Moreover, the effect of pressure has barely any influence of the final states of heat extraction, ORC power generation, and ORC efficiency. In case 2 where the pressure is preserved in the CMTHE, it is found that a decrease of flow rate in the CMTHE results in degradation of heat extraction, ORC power generation and ORC system efficiency. On the contrary, increasing the flow rate in the CMTHE leads to a rise of heat extraction, ORC power generation and ORC system efficiency. Unlike that in case 1, the effect of flow rate has a detectable effect on the final states of heat extraction, ORC power generation, and ORC efficiency

Long-Ranged Correlations in Sheared Fluids

The presence of long-ranged correlations in a fluid undergoing uniform shear flow is investigated. An exact relation between the density autocorrelation function and the density-mometum correlation function implies that the former must decay more rapidly than $1/r$, in contrast to predictions of simple mode coupling theory. Analytic and numerical evaluation of a non-perturbative mode-coupling model confirms a crossover from $1/r$ behavior at ''small'' $r$ to a stronger asymptotic power-law decay. The characteristic length scale is $\ell \approx \sqrt{\lambda_{0}/a}$ where $$ is the sound damping constant and $a$ is the shear rate.Comment: 15 pages, 2 figures. Submitted to PR

Shear-induced quench of long-range correlations in a liquid mixture

A static correlation function of concentration fluctuations in a (dilute) binary liquid mixture subjected to both a concentration gradient and uniform shear flow is investigated within the framework of fluctuating hydrodynamics. It is shown that a well-known $|\nabla c|^2/k^4$ long-range correlation at large wave numbers $k$ crosses over to a weaker divergent one for wave numbers satisfying $k<(\dot{\gamma}/D)^{1/2}$, while an asymptotic shear-controlled power-law dependence is confirmed at much smaller wave numbers given by $k\ll (\dot{\gamma}/\nu)^{1/2}$, where $c$, $\dot{\gamma}$, $D$ and $\nu$ are the mass concentration, the rate of the shear, the mass diffusivity and the kinematic viscosity of the mixture, respectively. The result will provide for the first time the possibility to observe the shear-induced suppression of a long-range correlation experimentally by using, for example, a low-angle light scattering technique.Comment: 8pages, 2figure

UK-based, multisite, prospective cohort study of small bowel obstruction in acute surgical services: National Audit of Small Bowel Obstruction (NASBO) protocol

Introduction Small bowel obstruction (SBO) is a common indication for emergency laparotomy in the UK, which is associated with a 90-day mortality rate of 13%. There are currently no UK clinical guidelines for the management of this condition. The aim of this multicentre prospective cohort study is to describe the burden, variation in management and associated outcomes of SBO in the UK adult population. Methods and analysis UK hospitals providing emergency general surgery are eligible to participate. This study has three components: (1) a clinical preference questionnaire to be completed by consultants providing emergency general surgical care to assesses preferences in diagnostics and therapeutic approaches, including laparoscopy and nutritional interventions; (2) site resource profile questionnaire to indicate ease of access to diagnostic services, operating theatres, nutritional support teams and postoperative support including intensive care; (3) prospective cohort study of all cases of SBO admitted during an 8-week period at participating trusts. Data on diagnostics, operative and nutritional interventions, and in-hospital mortality and morbidity will be captured, followed by data validation. Ethics and dissemination This will be conducted as a national audit of practice in conjunction with trainee research collaboratives, with support from patient representatives, surgeons, anaesthetists, gastroenterologists and a clinical trials unit. Site-specific reports will be provided to each participant site as well as an overall report to be disseminated through specialist societies. Results will be published in a formal project report endorsed by stakeholders, and in peer-reviewed scientific reports. Key findings will be debated at a focused national meeting with a view to quality improvement initiatives

Program Components and Results From an Organized Colorectal Cancer Screening Program Using Annual Fecal Immunochemical Testing.

Programmatic colorectal cancer (CRC) screening increases uptake, but the design and resources utilized for such models are not well known. We characterized program components and participation at each step in a large program that used mailed fecal immunochemical testing (FIT) with opportunistic colonoscopy. Mixed-methods with site visits and retrospective cohort analysis of 51-75-year-old adults during 2017 in the Kaiser Permanente Northern California integrated health system. Among 1,023,415 screening-eligible individuals, 405,963 (40%) were up to date with screening at baseline, and 507,401 of the 617,452 not up-to-date were mailed a FIT kit. Of the entire cohort (n = 1,023,415), 206,481 (20%) completed FIT within 28 days of mailing, another 61,644 (6%) after a robocall at week 4, and 40,438 others (4%) after a mailed reminder letter at week 6. There were over 800,000 medical record screening alerts generated and about 295,000 FIT kits distributed during patient office visits. About 100,000 FIT kits were ordered during direct-to-patient calls by medical assistants and 111,377 people (11%) completed FIT outside of the automated outreach period. Another 13,560 (1.3%) completed a colonoscopy, sigmoidoscopy, or fecal occult blood test unrelated to FIT. Cumulatively, 839,463 (82%) of those eligible were up to date with screening at the end of the year and 12,091 of 14,450 patients (83.7%) with positive FIT had diagnostic colonoscopy. The &gt;82% screening participation achieved in this program resulted from a combination of prior endoscopy (40%), large initial response to mailed FIT kits (20%), followed by smaller responses to automated reminders (10%) and personal contact (12%)